A proposed sustainability index for synthesis plans based on input provenance and output fate: application to academic and industrial synthesis plans for vanillin as a case study

• John Andraos

Beilstein J. Org. Chem. 2020, 16, 2346–2362, doi:10.3762/bjoc.16.196

• ) consumption, input enthalpic energy (IEE) consumption, Rowan solvent greenness index (RSGI), and sustainability index (SI). Keywords: Borda count; green chemistry; input enthalpic energy; process mass intensity; poset dominance analysis; Rowan solvent greenness index; sacrificial reagent; sustainability

• it along with process mass intensity (PMI), sacrificial reagent (SR) consumption, input enthalpic energy (IEE), and Rowan solvent greenness index (RSGI) as key attributes to rank any kind of synthesis plan or chemical process. PMI and IEE have already been defined in Equations 4 and 9. SR consumption

• and poset pairwise dominance algorithms according to the following attributes: process mass intensity (PMI), sacrificial reagent consumption (SR), input enthalpy energy consumption (IEE), Rowan solvent greenness index (RSGI), and sustainability index (SI). The Borda count method is found to be